Bombers target Israeli diplomats in India, Georgia

ALTERNATE CROP TO DEL847- An injured person is carried from a burning car belonging to the Israeli Embassy as it is in flames after an explosion, in New Delhi, India, Monday, Feb. 13, 2012. The wife of an Israeli diplomat was injured in the explosion, the same day as an Israeli Embassy staffer in Georgia found a bomb underneath his car, which was dismantled before exploding, according to Indian and Israeli media reports. (AP Photo/Joji Thomas, Economic Times) INDIA OUT- FULL CREDIT MANDATORY

ALTERNATE CROP TO DEL847- An injured person is carried from a burning car belonging to the Israeli Embassy as it is in flames after an explosion, in New Delhi, India, Monday, Feb. 13, 2012. The wife of an Israeli diplomat was injured in the explosion, the same day as an Israeli Embassy staffer in Georgia found a bomb underneath his car, which was dismantled before exploding, according to Indian and Israeli media reports. (AP Photo/Joji Thomas, Economic Times) INDIA OUT- FULL CREDIT MANDATORY

Indian security and forensic officials examine a car belonging to the Israel Embassy after an explosion tore through that, injuring two people in New Delhi, India, Monday, Feb. 13, 2012. Israel's prime minister accused Iran of being behind a pair of car bombings against Israeli diplomatic targets in India and Georgia. (AP Photo/Saurabh Das)

An injured person is carried from a burning car belonging to the Israeli Embassy following an explosion in New Delhi, India, Monday, Feb. 13, 2012. The wife of an Israeli diplomat was injured in the explosion, the same day as an Israeli Embassy staffer in Georgia found a bomb underneath his car, which was dismantled before exploding, according to Indian and Israeli media reports. (AP Photo/Joji Thomas, Economic Times) INDIA OUT, MANDATORY CREDIT

A worker sweeps debris as Indian police officers gather around car belonging to the Israel Embassy, that was damaged in an explosion in New Delhi, India, Monday, Feb. 13, 2012. The wife of an Israeli diplomat was injured in the explosion , the same day as an Israeli Embassy staffer in Georgia found a bomb underneath his car, which was dismantled before exploding, according to Indian and Israeli media reports.(AP Photo/Kevin Frayer)

A car belonging to the Israel Embassy, that was damaged in an explosion is moved to a police station, in New Delhi, India, Monday, Feb. 13, 2012. The wife of an Israeli diplomat was injured in the explosion , the same day as an Israeli Embassy staffer in Georgia found a bomb underneath his car, which was dismantled before exploding, according to Indian and Israeli media reports.(AP Photo/Kevin Frayer)

(AP) ? Israel blamed Iran on Monday for bomb attacks on its diplomats' cars in India and Georgia, heightening concerns that the Jewish state was moving closer to striking its archenemy.

Iran denied responsibility for the attacks that appeared to mirror the recent killings of Iranian nuclear scientists that Tehran blamed on Israel.

The blast in New Delhi set a car ablaze and injured four people, including an Israeli Embassy driver and a diplomat's wife; the device in Georgia was discovered and safely defused.

"Iran is behind these attacks and it is the largest terror exporter in the world," Israeli Prime Minister Benjamin Netanyahu told lawmakers from his Likud Party.

The violence added further tension to one of the globe's most contentious standoffs. Iran has been accused of developing a nuclear weapons program that Israel says threatens the existence of the Jewish state. Tehran says its nuclear program is for peaceful purposes only.

Comments by Israeli officials in recent weeks have raised fears Israel might be preparing to strike Iranian nuclear facilities. While Israel says it hopes that international sanctions can curb Iran's nuclear program, leaders pointedly note that "all options are on the table" and have warned that as Iran moves closer to weapons capability, time is running out for action. Fearing an Israeli attack could set off a conflict across the region and send oil prices skyrocketing, U.S. and other Western countries have been pressing Israel to give sanctions more time.

Israeli military analyst Reuven Pedatzur said Monday's action was unlikely to have any bearing on whether Israel attacks Iran, calling it an "isolated incident" with rather low impact.

The attackers in India and Georgia appeared to have used "sticky bombs" attached to cars by magnets, similar to weapons used against Iran's nuclear officials. Netanyahu said Israel had thwarted attacks in recent months in Azerbaijan and Thailand and unspecified other countries.

"In all those cases, the elements behind these attacks were Iran and its protege, Hezbollah," Netanyahu said, referring to Iran's Lebanese proxy. He vowed to "act with a strong hand against international terror."

Israeli media reported that the government blamed Iran based on prior intelligence and that security officials feared this could be the start of a wave of attacks against Israeli targets overseas.

Iranian officials rejected Netanyahu's accusation.

"This accusation is within the Zionist regime's psychological war against Iran," the official IRNA news agency quoted Foreign Ministry spokesman Ramin Mehmanparast as saying.

"The Zionist regime, due to repeated crimes against humanity, is the main party accused of terrorist activities," he said, according to IRNA.

The New Delhi attack took place just after 3 p.m. a few hundred yards (meters) from the prime minister's residence as the diplomat's wife headed to the American Embassy School to pick up her children, said Delhi Police Commissioner B.K. Gupta.

When the minivan approached a crossing, she noticed a motorcyclist ride up and stick something on it that appeared to be a magnetic device, he said. The car drove a short distance, there was a loud sound and then an explosion, and the car caught fire, he said.

"It was a loud explosion. We realized it's not a firecracker, but an explosion, and rushed toward the car," said Ravi Singh, owner of a nearby gas station.

The blast left the vehicle charred and appeared to blow out its rear door.

"The blast was so powerful, the car behind got damaged as well," said Monu, a high school student who uses only one name.

The Israeli Defense Ministry said the woman, Tal Yehoshua-Koren, the wife of a Defense Ministry official based in New Delhi, suffered moderate shrapnel wounds and was treated at a hospital by Israeli doctors.

Her driver, Manoj Sharma, 42, and two people in a nearby car had minor injuries, Gupta said.

Israeli diplomats in India have been on constant alert since Pakistan-based militants rampaged across the Indian city of Mumbai in 2008, targeting luxury hotels, a train station and the Chabad Jewish community center.

India's foreign minister, S.M. Krishna, said India would cooperate closely with Israel in the investigation and promised to bring the assailants to justice.

"I have just spoken to the Israeli foreign minister," he said. "I assured him that the law of the land will take its course."

Authorities in the former Soviet republic of Georgia said an explosive device was planted on the car of a driver for the Israeli Embassy in the capital of Tbilisi.

Shota Utiashvili, spokesman for the Georgian Interior Ministry, said the driver noticed a package on his car's undercarriage and called police, who found and defused a grenade.

U.S. Secretary of State Hillary Rodham Clinton condemned the attacks.

"The United States places a high priority on the safety and security of diplomatic personnel around the world and we stand ready to assist with any investigation of these cowardly actions," she said.

White House spokesman Jay Carney said the incidents underscore U.S. concerns about the recent targeting of Israeli interests overseas. He added that Washington does not yet have information on who is responsible for the attack but stands ready to help the investigations.

Iranian lawmaker Javad Jahangirzadeh was quoted by the semiofficial Mehr news agency as saying the Israeli charges were meant to provoke the world against Iran and to undermine upcoming nuclear talks between Tehran and the world powers.

Another lawmaker, Avaz Heidarpour, was quoted by Mehr as saying Netanyahu's allegations were an attempt by Israel to justify future operations against Iran.

"It's very likely that the Zionist regime is paving the way to carry out an assassination abroad or hit inside Iran. So, they are making preparations for that," Mehr quoted him as saying.

Hezbollah and Iran have deep grievances against Israel.

Hezbollah battled Israel in a monthlong war in 2006. On Sunday, the Lebanese guerrilla group marked the anniversary of the 2008 assassination of one of its commanders, Imad Mughniyeh, in a bombing widely believed to have been carried out by Israel. Iran has been widely suspected of looking for payback for the covert plots against its nuclear program it has blamed on Israel's spy agency Mossad and Western allies.

"There have been all kinds of mysterious things happening in Iran, and it could be an Iranian counterattack," said Mike Herzog, a retired Israeli general and former top aide to Israeli Defense Minister Ehud Barak. "It's no secret that Iran uses Hezbollah globally, and Hezbollah has the capacity to carry out attacks around the globe."

Iran and Hezbollah also could be trying to divert attention away from ally Syria's crackdown on protesters.

Were Iran found to be behind the New Delhi attack, it would be a stunning action against one of its more reliable allies.

Indian Prime Minister Manmohan Singh has resisted U.S. and European Union pressure to curtail trade with Iran over the nuclear issue. Energy-starved India relies heavily on Iranian oil imports, and the two countries are working to find creative ways for India to circumvent banking restrictions to pay for the oil by using rupees and investing in Iranian infrastructure projects.

Israel has urged the international community to consider all means, including military action, to stop Tehran.

Last month, a director of Iran's main uranium enrichment site was killed in a blast from a magnetic bomb placed on his car, at least the fifth member of Iran's scientific community killed in apparent targeted attacks in two years.

In a signal Iran could retaliate, Gen. Masoud Jazayeri, the spokesman for Iran's Joint Armed Forces Staff, was quoted by the semiofficial news agency ISNA last month as saying that Tehran was "reviewing the punishment" of "behind-the-scene elements" involved in the assassination.

"Iran's response will be a tormenting one for supporters of state terrorism," he said. "The enemies of the Iranian nation, especially the United States, Britain and the Zionist regime, or Israel, have to be held responsible for their activities."

Clinton categorically denied any U.S. link to an "act of violence inside Iran." Israel has made no direct comments about Iran's accusations of covert operations, but some officials have made provocative hints that Tehran's many foes could have an interest in efforts to destabilize its nuclear program.

Iran also has blamed the U.S. and allies for a sophisticated computer virus, known as Stuxnet, that was programmed to disrupt the centrifuges used in uranium enrichment. Iran said the virus was detected in its systems, but added there were no serious setbacks.

In January, a foreign suspect with alleged links to Hezbollah militants led Thai police to a warehouse filled with materials commonly used to make bombs.

In 1992, a bombing at the Israeli Embassy in Buenos Aires killed 29 people. Two years later, a bombing at a Jewish community center there killed 85 people. Argentines have long suspected high-level Iranian diplomats were involved in the 1994 bombing.

___

Federman reported from Jerusalem. Associated Press writer Misha Dzhindzhikhashvili in Tbilisi and Julie Pace and Matthew Lee in Washington contributed to this report. Follow Nessman at http://www.twitter.com/ravinessman and Federman at www.twitter.com/joseffederman

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-02-13-Israel-Attacks/id-17df51dc647745518f528fa47d5b3b2d

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Dad Addresses Viral Laptop Shooting After Daughter's Facebook Post [QUOTES] (Mashable)

The tech-savvy, gun-toting father who blasted nine hollow-point rounds into his daughter's laptop after she wrote a disrespectful Facebook post is dealing with his newfound notoriety much the same way he handled the girl's rant: publicly and proactively. If you haven't seen the now-viral video, here's what happened: Tommy Jordan of North Carolina has a 15-year-old daughter who posted an indignant note to Facebook in which she complained about and harshly criticized her parents for forcing her do too many chores around the house and generally making her life a hassle.

[More from Mashable: Google to Get Scary With Anne Rice]

She thought she'd hid it from her parents using privacy settings, but her father works in IT and found the note anyway, he said, when he was uploading photos to the family dog's profile page. (She didn't think to hide it from the dog.) So he decided to reprimand her publicly, saying in the video that ?since you want to hide it from everyone, I?m going to share it with everybody.?

He posted an eight-minute video to YouTube on Wednesday, refuting her key points and reading the entire note aloud while smoking a cigarette and sitting in a wooden chair in a grassy field. After about seven minutes of preamble, he gets up, points the camera at a laptop on the ground, introduces a pistol into the frame -- ?This right here is my .45" -- and blasts away.

[More from Mashable: French Prez Nicolas Sarkozy Turns On, Fills Up His Facebook Timeline]

Not surprisingly, the video took off. When Mashable wrote about it the day after it was posted, it had just over 5,000 YouTube views. Now it has 15 million.

SEE ALSO: Dad Shoots Daughter?s Laptop Over Facebook Post [VIDEO]

According to Facebook posts by Jordan, he has since received more media inquiries than he can handle, sponsorship requests, and a deluge of both hateful and supportive messages from people eager to provide feedback on his parenting methods.

Jordan addressed the laptop shooting and subsequent hullaballoo in a recent Facebook post that begins, "Attention Media Outlets:"

While we appreciate the interest you?re all putting forth to get in touch with us regarding the video, we?re not going to go on your talk show, not going to call in to your radio show, and not going to be in your TV miniseries.

Some of you think I made an acceptable parenting decision, and others think I didn?t. However, I can?t think of any way myself or my daughter can respond to a media outlet that won?t be twisted out of context. The Dallas news TV news already showed that in their brief five-minute interview with the psychologist.

Jordan goes on to say that exploiting the media glare would send his daughter the wrong message "that it's OK to profit at the expense of someone else's embarrassment or misfortune, and that's not how I was raised, nor how she has been raised." Jordan says in the post that he will make any further comments through his Facebook page, not through the media. "My daughter isn?t hurt, emotionally scarred, or otherwise damaged," he writes, "but that kind of publicity has never seemed to be to have a positive effect on any child or family."

In subsequent posts, Jordan sheds more light on the zoo his life has become, further explains the reasoning behind his laptop assassination, solicits funds for the Muscular Dystrophy Association, and promotes a social selling website he's been helping to build. Many of his posts have received well over a thousand comments.

Here, in the gallery below, are several snippets of what Tommy Jordan has had to say over the past couple days. For the full versions, head on over to his Facebook page.

What do you think about this video going viral and Jordan's following response? Let us know in the comments.

1. "Never again..."


In a post from Friday, Jordan says he was unprepared for the attention the video attracted.

Click here to view this gallery. This story originally published on Mashable here.

Source: http://us.rd.yahoo.com/dailynews/rss/personaltech/*http%3A//news.yahoo.com/s/mashable/20120211/tc_mashable/dad_addresses_viral_laptop_shooting_after_daughters_facebook_post_quotes

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Why Bodybuilding Supplements To Build Up Muscle Mass For The ...

February 11, 2012 by scott

Sports enthusiasts aren?t the only ones getting into bodybuilding but likewise ordinary men and women. Each day more and more people do bodybuilding since they comprehend the numerous health positive aspects of weight training and exercise. So, what was once thought of a recreation developed into a big sporting sector with financial ventures not just in sporting products but in bodybuilding supplements in the process.?
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It?s thought that bodybuilding supplements could help endorse muscle growth. Hence, if a sports athlete wishes to be the ideal and acquire recognition and fortune, he ought to accumulate with different kinds of bodybuilding supplements. Nonetheless the fact is, not all bodybuilding supplements are proven and tested beneficial in offering their commitment.?
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The majority of bodybuilding supplements contain ingredients which form naturally within the body. Because of this, you?ll discover quite few complications associated with using bodybuilding supplements. Looseness of the bowels and upset stomach are some of the most frequent unwanted side effects of bodybuilding supplements. Most negative effects go away within a few weeks. Critical side effects could be experienced with a few supplements, though none with a few.
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It is usually recognized that protein is crucial to anyone who is a determined weight trainer. Protein is important particularly for bodybuilders as it is necessary to build and repair muscles. You can have a lot more protein in your diet in several ways. One of the most common methods to supplement protein is with whey protein isolate. You could include it with smoothies or several other drinks and food. This protein supplement could be conveniently absorbed by the body. In addition to whey protein, several other protein supplements contain egg whites, the milk protein casein, and soy protein. Meat is not an excellent source of protein particularly for bodybuilders or individuals who would like to build muscle mass simply because it is in addition loaded with fat. Regardless of this fact, protein is still considered because the most reliable bodybuilding supplements you can take to accomplish your purpose. It is important to pick the appropriate protein supplement; one that could be effortlessly utilized and with less fat.?
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As food enhancer, bodybuilding supplements stimulate the muscle build-up through tension. Bodybuilding supplements are becoming a major necessity for people who want to build up muscles. In our current world, one may well discover numerous manufacturers participating in creating a wide number of supplements; however, one could decide on the ideal supplements sensibly focusing on the required objectives and goals. Furthermore, some of these supplements might have unwanted side effects, which can be mild to severe. It for that reason pays to be mindful in selecting a particular supplement.?
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One should recognize that bodybuilding supplement is a significant sector as described previously mentioned. It is a truth that these supplements help develop lean muscle mass and reduce fats, but unfortunately there?s also some kind of marketing hype associated. Promotions have to be considered with a bit of criticism and folks shouldn?t acknowledge everything it says. Consequently choosing the proper bodybuilding supplements is not just for building muscle mass nonetheless also for promoting overall wellness. You must speak to your doctor or well-being expert about the usage of these supplements to prevent any side effects later.


Source: http://miamiaug.com/?p=427

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Breathe Easier From This Great Asthma Advice - Health and Fitness ...

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Source: http://www.healthandfitnessarticlesblog.com/breathe-easier-from-this-great-asthma-advice/

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Safe Diet Pills | New Health and Fitness

New Health And Fitness.Org - Health Information You Can Use

Losing weight is something that the majority of people struggle with at some point in their lifetime. Whether its a few extra pounds or one is considerably overweight, it still takes a good deal of work and dedication to get the weight off. Being overweight can effect ones life in a number of negative way. Not only is ones physical health at risk, but it can be extremely tolling on ones mental health. Finding a successful way to get the weight off and keep it off is important.

Some dieting aids provide a significant increase in weight-loss in the beginning and then progress tends to taper off because of increased tolerance to the drug. This usually results in discouragement. Users of weight loss natural pills take them as part of a daily routine of diet and exercise and their progress is more integrated into their habits.

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Any weight loss formula will advise against overeating. It takes the body approximately 20 minutes to alert the mind that the stomach is full and to stop sending hunger signals. Eating slowly gives the body that 20 minutes and also allows savoring of the food. Eating slowly means taking the time to set down the knife and fork between each bite. The second way to not overeat is to simply keep portions to a decent size and the meal to a single helping. If the hunger persists, wait 20 minutes before deciding if a second helping is necessary.

One could research herbs for months, trying to discover which herbs are best suited for their particular needs. There are many resources for purchasing herbs in bulk, in tea form, or fresh, or dried, or powders. So a person could potentially create their own herbal concoction, experimenting with different herbs and quantities to find out what works best for their bodies. This could take a very long time, and a person would need a comprehensive understanding of herbs. Weight loss herbal pills, however, give you a proven balance of powerful herbs to support your weight loss goals.

Natural diet pills are always a better choice than any other type of diet pills if only because you always know exactly what you are putting into your body. Knowing exactly what is being eaten or drank or just flat out consumed is an important part of managing your weight and not having pills filled with chemicals most people cant pronounce is a great factor in that. If you want to be one of those Americans that joins the fad of weight loss attempts you need to make sure you are doing it the most intelligent way and using a Slimway natural weight loss product is the best around.

Would you like to learn more about medical weightloss ? Most Helpful Diet Plan Requires Goal Setting, then check out our site and learn more about Lose 2Kg Per Week! How to Lose 2 Kg Per Week!.

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Source: http://newhealthandfitness.org/2012/02/10/safe-diet-pills-5/

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Best Family Vacation Destinations ? Hot to Cold

Some people prefer moving south to enjoy the weather for a great family vacation, while others head up north to have winter fun. Regardless of your options, you need to understand the details first to ensure that every member will have a great time. There are plenty of places offering various activities and excellent accommodations at a good price.

Hiking Highlights

Hiking is an all-American favorite pastime and there are several sites around the United States where you can enjoy great weather and terrain all-day long. Try out Baxter Mountain Trail in New York with the clan. You can join the Adirondack hiking trip that shows you great views of Keene Valley and the High Peaks. The entire trip is about 2.2 miles long from Spruce Hill. Kindergartens are able to go through the course well. The best times to visit is between May and October to get away from slippery snow.

Deer Mountain in Colorado is a great hiking spot for teenagers and adults.

The trail runs 6 miles long featuring spots like Rocky Mountain National Park, Longs Peak and Deer Ridge. The best time to go is between June and September.

Moving to Mexico

Mexico City is a great place for big families. You can check out Chapultapec Park which has pony rides, amusement parks, water parks, a big zoo, bicycle rentals and rowboats. There are also concerts on weekends and Segway tours. Some of the features of the shows are costumed acrobats, Aztec pole dancers and ballets. The park also features El Museo del Nino or Museum of the Child that is very educational for young kids and adults. The National History of Museum used to be home of Emperor Maximilian.

The entire family can enjoy different tastes and sights around town too.

You can find great rustic hotels to experience authentic Mexican culture. There are several restaurants and bars around too where you can enjoy delicious appetizers and drinks. Witness the bustling night life of Mexico City with the numerous clubs and lounges.

Cancun Fun

Cancun is one of the best places to go if you want to do several activities with the whole family. Cancun has several beaches where you can snorkel, surf, sail, dive, sunbathe, jet ski and kayak. Several hotels near the beach have turtle rescue programs, so your kids may consider adopting one. Parque Nizuc is found at the south end of Cancun where kids and adults can enjoy the water park and dolphin swim program. There is an Interactive Aquarium and rock climbing wall too.

Winter Resorts

Ski resorts are very ideal for family vacations too. You can visit Copper Mountain in Colorado where you can try snowboarding and skiing. The resort also features several winter amenities and a restaurant serving hot cocoa and delicious breakfast. Winter Park is another ski resort in Colorado that features sunshine 106 days every year. Kids can take lessons in skiing and snowboarding. Ski condos are conveniently near the location so you get great views throughout your stay.

Aspen is a must-visit place for families. Take a look at the famous peaks like Snowmass Mountain, Aspen Mountain and Buttermilk Mountain. There is a ski school where kids and amateurs can immediately learn how to ski the right way. Vacation rentals are good options for budget-conscious families.

Lisa McLaughlin is a frequent writer on travel and has a wide collection of articles, news, advice and tips on a wide range of travel types and destinations on her Travel and Vacation Tips site along with some Free Travel Guides.

Source: http://www.1directory.net/travel-and-leisure/best-family-vacation-destinations-hot-to-cold-2817.html

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Venture Capital Fund: A Viable Risk? | Personal Finance Blogs ...

Venture capital fund is considered one of the financing options of a business. A venture capital firm will give a business its much needed funds and first class resources to become an industry player. Seeking out venture capitalists may play a huge role for a company who needs to needs rapid growth and success. Unfortunately even though they may provide a good opportunity there are also disadvantages in acquiring venture capital fund.

Finding potential investors have side effects before and after they approve your business plan. The competition is very stiff. Investors do not care about an entrepreneur?s hopes and dreams. They care about financial projections and earning more money than they invested in a short period of time. In exchange for the money your need; the investors will bite a chunk out of your business and control.

The grass isn?t entirely greener on the other side.

A private equity firm may give you the cash that you need to boost up your business but nothing is free. After all, this is business and money dictates everything. Venture capitalists already have an effect on your business at the start of your application.

Large and established venture capital firms only approve less than 10% of the business plans they come across. Established businesses with a good track record and posses a huge potential are the only ones who have the chance of getting approved.

Private equity firms also invest in specific industries, technologies and geographical area. There are different types of firms but large ones are interested in high technology businesses. You must find a firm that will suit your business and more importantly a product innovative enough to cause interest.

Raising equity to finance your business is time consuming, demanding and costly. Investors will also probe you and your business. During your presentation they will be very critical of your historical financial data, future projections and management team.
They will also evaluate your business? investment potential.

Once they have decided to invest in your business, they will present their term sheet. This will contain the investment deal including the terms and conditions of the investor. Negotiations will follow between you and the venture capital firm. The most important aspect in this negotiation is the valuation of the business.

This will determine the amount of equity that you will give in exchange for the fund. Investors will require 30% to 40% of equity from your business. This will enable them to exercise their influence and gain a say in your company?s decisions.

Due to this the ownership of the company will be diluted. You also have to provide time to be able to provide information to the investors who will be monitoring your company. You also have to adhere to legal and regulatory issues.

Investors aim to earn money three to five times more than they invested in five years. They will accomplish this by selling their equity or to public stock markets.

All in all using venture capital as a financial option comes with risks. If you are an entrepreneur who doesn?t mind sacrificing a chunk of your business for rapid success then this option suits you.

Be reminded however that securing a venture capital is an arduous process even after you have attained it. Be ready for some additional players in the table.

Read Recent Articles by the same Author about Cyprus Hotels

Source: http://mysurefinance.com/venture-capital-fund-a-viable-risk/

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Alzheimer's Disease Symptoms Reversed in Mice

News | Mind & Brain

A cancer drug given to mice eliminates brain-damaging proteins, leading to improved cognition within days, but will it work in humans?


A nearly 13-year-old skin cancer drug rapidly alleviates molecular signs of Alzheimer's disease and improves brain function, according to the results of a new mouse study being hailed as extremely promising. Early-stage human clinical trials could begin within months.

In the study, published?online in today in Science, researchers from Case Western Reserve University in Cleveland and colleagues used mice genetically engineered to exhibit some of the symptoms of Alzheimer's. Most notably, the mice produced amyloid beta peptides?toxic protein fragments that gum up neurons and lead to cell death?and showed signs of forgetfulness.


Amyloid beta (red areas) peptides clear from the brain of an Alzheimer's mouse after three days of treatment with a cancer drug (right image). Source: AAAS/Science

The Case Western team, led by Gary Landreth, decided to try the drug bexarotene (Targretin), approved in 1999 for cutaneous T cell lymphomas. The team chose this drug because of its long experience working with proteins in the nucleus of brain cells that can induce biochemical processes that affect amyloid beta.

Landreth and his colleagues fed bexarotene to the demented mice, and with just a single dose it lowered the most toxic form of the amyloid beta peptide by 25 percent within six hours, an effect that lasted for up to three days. Mice that were cognitively impaired by the amyloid buildup resumed normal behaviors after 72 hours: They began to crinkle toilet paper placed nearby to make nests, a skill lost as amyloid increased in their brains.

"We have successfully reversed all of the known pathological features and behavioral deficits found in mouse models of Alzheimer's disease," Landreth says. "Never before has anyone observed clearance of amyloid plaques with such speed in mouse models."

Other Alzheimer's researchers hail the work. "I think this is extremely promising," says Samuel Gandy, a professor of neurology and psychiatry at Mount Sinai School of Medicine and associate director of the hospital's Alzheimer's Disease Research Center. "One of the drugs that has been on our wish list for 25 years is a drug that would clear existing amyloid deposits."

"Landreth's paper is impressive," adds Kenneth Kosik, a neuroscientist at the University of California, Santa Barbara. "The effects in mice, including some restoration of cognitive abilities, are dramatic."

Neural sanitation
In a field littered with drug failures, the study offers hope that the strategy of clearing the brain of the toxic peptide can work. Bexarotene does not do so directly, however; instead, it activates retinoid receptors on brain cells that increase production of a fat-protein complex, apolipoprotein E, that helps rid excess amyloid in the fluid-filled space between neurons. It also appears to enhance another cleanup process, called phagocytosis.

Bexarotene functions differently than an amyloid-clearance approach using monoclonal antibodies, which are further down the drug development pipeline. These antibodies bind directly to amyloid and then remove it, but they have sometimes caused fluid to fill brain tissue. Bexarotene may be less likely to cause such swelling. "I think the fact that we're inducing a natural process by turning on these receptors doesn't lend itself to water on the brain," says Paige Cramer, Landreth's graduate student who performed much of the research. Unlike bexarotene, which is taken orally, monoclonals are more troublesome to administer, because they must be delivered intravenously, and if they receive U.S. Food and Drug Administration approval, they would likely be significantly more expensive.

Source: http://rss.sciam.com/click.phdo?i=e52e97921e35c4818c7f088578fe1fa1

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Virginia Hospital Center & TriColumbia Announce Inaugural ...

Columbia, Md. ? Virginia Hospital Center, a leading comprehensive healthcare facility in the Washington Metropolitan area, and TriColumbia, the Mid-Atlantic?s premier endurance event production company, announced today that the inaugural EnduraHealth Summit race season kick-off will take place on Saturday, March 3, 2012 from 10 a.m. ? 1 p.m. at the John T. Hazel, MD Conference Center at Virginia Hospital Center.

EnduraHealth Summit will provide guidance and information on training, preparation, nutrition and recovery for endurance athletes, ranging from first-time triathletes and marathoners to ?weekend warriors,? and help them to prepare and remain healthy this race season. The summit will include a Meet & Greet with local professional triathletes and a Q&A with several renowned doctors from Virginia Hospital Center.

Among the panel of experts will be an athletic cardiologist, general care physician, pulmonologist Dr. Jeff Hales and orthopedic surgeon Dr. Ben Kittredge. Dr. Hales studied at Duke University, Vanderbilt University, and Johns Hopkins University, gaining experience in internal, pulmonary, and critical care medicine. Hales is the Chief of the Pulmonary, Critical Care and Sleep Division at Virginia Hospital Center and specializes in specializes in lung medicine with a focus on airways disorders such as asthma.

Dr. Ben Kittredge has always had a desire to work with and care for athletes of all kinds. As a runner himself, Kittredge has taken a special interest in running and triathlon injuries. While completing fellowships in sports medicine at Jefferson Medical College and Pennsylvania Hospital in Philadelphia, Pa., Kittredge nurtured his interest in sports medicine by serving as assistant team physician for the Philadelphia Eagles, Flyers and Phillies. His surgical specialties include ACL reconstruction and arthroscopic shoulder stabilization.

?We are very excited to work with the experts at TriColumbia to prepare local endurance athletes for race season,? said Adrian Stanton, Vice President and Chief Marketing Officer at Virginia Hospital Center. ?It is essential for these athletes to learn how to prepare and take care of their bodies and we thought the EnduraHealth Summit would be a great opportunity to make sure everyone in informed and healthy for the upcoming race season.?

Local professional triathletes Kyle Pawlaczyk (Virginia) and Kristin Andrews (Maryland) will also be on hand to answer athletes? questions and share tips on how to prepare for and recover from endurance events. Pawlaczyk, entering this third year as a professional triathlete, has recorded several top-five and top-ten finishes, including a fifth place finish Ironman 70.3 Poconos and an eighth place finish at Ironman 70.3 EagleMan. Andrews celebrates her inaugural pro season in 2011 with a first place finish at the Iron Girl Columbia Triathlon and a second place finish at the Racine Ironman. Before turning pro, she set an amateur record by 10 minutes at the 2010 Ironman Lake Placid.

?EnduraSummit is a great way to prepare endurance athletes of all backgrounds and experience levels for the 2012 race season,? said Robert Vigorito, President and founder of TriColumbia. ?We are excited to have the opportunity to work with the Virginia Hospital Center and are looking forward to a successful inaugural event.?
Interested vendors should contact Eve Hemsley at (443) 864-4246 or Eve@MaroonPR.com.

For more information and to RSVP, visit http://endurahealthsummit.eventbrite.com.

About Virginia Hospital Center

For over 60 years, Virginia Hospital Center has provided exceptional medical services to the Washington metropolitan area. Virginia Hospital Center is a 342-bed, $150 million state-of-the-art facility?offering comprehensive healthcare and multiple Centers of Excellence including Cardiology & Cardiovascular Surgery, the Reinsch Pierce Family Center for Breast Health, Neuroscience, Oncology, Total Joint Replacement (hip and knee), Women & Infant Health and Urology. Growing service lines include Executive Health and the only Lung Cancer Center in northern Virginia. Virginia Hospital Center is a teaching hospital, long-associated with Georgetown University?s School of Medicine, and accredited by The Joint Commission and Licensed by the Commonwealth of Virginia Department of Health.? For additional information, please visit www.virginiahospitalcenter.com.

About TriColumbia

TriColumbia is a 501 (C)(3) nonprofit and the Mid-Atlantic?s premier endurance event production company providing an array of events for all ability levels across the triathlon/multisport continuum.? Founded by current president, race director and 6-time Ironman Kona finisher, Robert Vigorito in 1983, the organization makes a difference for participating athletes by providing superior events and memories to last a lifetime, but also gives back to the community by supporting many local and regional charities, which provide a full spectrum of support for citizens in need.? For more, visit TriColumbia.org.

CONTACT:

Kristen Peifer Dugan
Public Relations Director, Virginia Hospital Center
kpeifer@virginiahospitalcenter.com
703.558.6595

Linda Congedo
Director of Communications, Columbia Triathlon Association
Linda@TriColumbia.org
410-794-6993

Chris Daley
Maroon PR
Chris@MaroonPR.com
443-864-4246

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Source: http://endurancesportswire.com/virginia-hospital-center-tricolumbia-announce-inaugural-endurahealth-summit/

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