odumeuf's posterous http://odumeuf.posterous.com Most recent posts at odumeuf's posterous posterous.com Wed, 16 Jan 2013 16:43:32 -0800 Harvard Medical to power Orca's reference apps | mobihealthnews http://odumeuf.posterous.com/harvard-medical-to-power-orca39s-reference-ap http://odumeuf.posterous.com/harvard-medical-to-power-orca39s-reference-ap

Orca Health HeartDecideMedical reference app and iBook maker Orca Health announced a partnership with Harvard Medical School this week. Starting with Orca?s existing HeartDecide app, Harvard Medical will begin supplying the content for Orca?s interactive apps while Orca continues to focus on design and engineering.

Orca began as a hobby for CEO Matt Berry, whose father is a spine surgeon in Salt Lake City, Utah, where the company is built. Orca?s iOS apps are designed to help educate surgery patients about their bodies and their surgical options, to aid them in making medical decisions. They include 3D models, interactive animations, narrated videos, and a ?Find A Specialist? feature, in partnership with provider locator platform DocSpot. The company?s EyeDecide app was named medical app of the year by Apple for 2011.

?We?re no longer a text-based society,? said Berry. ?A surgeon shouldn?t give out pamphlets anymore, they ought to prescribe multisensory learning apps.?

The new HeartDecide app will have all new content, some of it from existing Harvard Medical materials and some created expressly for the app by Harvard Medical School physicians. In addition, it will have added features, updated graphics, and a faster download time. Orca?s health content was previously written by Orca?s team of board-certified physicians. Berry said they will stay involved as the company gradually replaces the content in each of the company?s 13 apps with content from Harvard.

Orca is also releasing a series of interactive iBooks on particular cardiovascular conditions like angina and atherosclerosis. These are aimed less for patient education and more as e-textbooks for K-20 education (kindergarten through medical school). They are also written by Harvard Medical doctors, modified from existing special reports.

Berry said Orca and Harvard Medical School were connected through a mutual friend at incubator Rock Health (although Orca didn?t go through that incubator). He said the team at Harvard Medical School shares his views about text becoming obsolete.

?Many things can be explained better with video, interactive animations and spoken voice?not just plain text,? Dr. Anthony Karmaroff, editor in chief of Harvard Medical publishing, said in a statement. ?Harvard Medical School believes its partnership with Orca Health will enable people to access, understand and retain high quality health information via state-of-the-art technology.?

In addition to plans for an Android launch in the near future, Berry said the company?s future direction is to create a more comprehensive, linear solution for patient education, moving from a single app, both for patients and for physicians to use as a teaching tool, to separate apps connected by ?an Orca cloud that meets in the middle.?

The company?s apps are currently available on iOS devices only, normally at $4.99. To celebrate the partnership with Harvard Medical School, the company is temporarily making all their apps free. The iBooks are $4.99 apiece.

Source: http://mobihealthnews.com/19877/harvard-medical-to-power-orcas-reference-apps/

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Tue, 15 Jan 2013 21:19:16 -0800 Full City Kitty: Washington DC Coffee Cat Needs A Loving Home ... http://odumeuf.posterous.com/full-city-kitty-washington-dc-coffee-cat-need http://odumeuf.posterous.com/full-city-kitty-washington-dc-coffee-cat-need

130114112206_coffeebean

This Full City kitty deserves a permanent home and family to snuggle with. Her name is Coffee Bean, and she?s the Washington Animal Rescue League?s pet of the week. If we had it our way, we?d give this coffee cat a 90+. More from WUSA9:

?Coffee Bean is a beautiful two-year-old tortie with a fun and entertaining personality.

Although she proudly demonstrates the typical ?tortitude? traits of being intelligent, strong-willed, independent and feisty, Coffee Bean is not your ordinary tortie.

This girl is one really smart cookie, who will high-five and purr for treats and has been developing her tail-chasing skills. And like most females, she enjoys being pampered by a good head and neck massage.?

If you wanna take this snuggle-pie home, contact WARL to arrange a meet-up with its foster family. Please send us photos after this happens, and thank you.

Source: http://sprudge.com/washington-dc-coffee-cat-needs-a-loving-home.html

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Tue, 15 Jan 2013 19:30:30 -0800 AP PHOTOS: A look back at Lance Armstrong's career http://odumeuf.posterous.com/ap-photos-a-look-back-at-lance-armstrongs-car http://odumeuf.posterous.com/ap-photos-a-look-back-at-lance-armstrongs-car AAA??Jan. 15, 2013?2:31 AM ET
AP PHOTOS: A look back at Lance Armstrong's career
By The Associated Press?THE ASSOCIATED PRESS STATEMENT OF NEWS VALUES AND PRINCIPLES?By The Associated Press

FILE - In this July 23, 2000, file photo, winner Lance Armstrong rides down the Champs Elysees after the final stage of the Tour de France cycling race in Paris. Armstrong also won the Prince of Asturias Award in Sports in 2000. Armstrong was stripped of his seven Tour de France titles and banned for life by cycling's governing body following a report from the U.S. Anti-Doping Agency that accused him of leading a massive doping program on his teams. (AP Photo/Laurent Rebours, File)

FILE - In this July 23, 2000, file photo, winner Lance Armstrong rides down the Champs Elysees after the final stage of the Tour de France cycling race in Paris. Armstrong also won the Prince of Asturias Award in Sports in 2000. Armstrong was stripped of his seven Tour de France titles and banned for life by cycling's governing body following a report from the U.S. Anti-Doping Agency that accused him of leading a massive doping program on his teams. (AP Photo/Laurent Rebours, File)

FILE - In this July 1, 1999, file photo, cyclists Jonathan Vaughters, left, and Lance Armstrong, both of the United States, joke around during medical checks for the Tour de France cycling race at Le Puy du Fou, western France. Armstrong was diagnosed with stage three testicular cancer in 1996. The tumors had spread to his abdomen, lungs, and lymph nodes. Vaughters later testified that he saw Armstrong inject himself in the stomach in 1998. (AP Photo/Michel Spingler, File)

FILE - In this July 15, 1999, file photo, the U.S. Postal Service team including, from left, Christian Vandevelde, Peter Meinert-Nielsen, of Denmark, Pascal Derame, of France, Kevin Livingstone, George Hincapie, Frankie Andreu, Lance Armstrong and Tyler Hamilton, controls the pack during the 11th stage of the Tour de France cycling race between Le Bourg D'Oisans and Saint-Etienne, central France. Armstrong won his first Tour de France title in 1999_but in 2012 Armstrong was stripped of his seven Tour de France titles and banned for life by cycling's governing body. (AP Photo/Laurent Rebours, File)

FILE - In this July 25, 1999, file photo, winner Lance Armstrong holds up the trophy on the podium after the final stage of the Tour de France cycling race between Arpajon and Paris. Armstrong won his first Tour de France title in 1999_but in 2012 Armstrong was stripped of his seven Tour de France titles and banned for life by cycling's governing body following a report from the U.S. Anti-Doping Agency that accused him of leading a massive doping program on his teams. (AP Photo/Michel Spingler, File)

FILE - In this April 9, 2001, file photo, Lance Armstrong, left, appears during a news conference regarding doping accusations in Paris, as his lawyer Georges Kiejman watches. After a decade of denial and being stripped of his titles, Armstrong has finally come clean_ During an interview with Oprah Winfrey taped Monday, Jan. 14, 2013, Armstrong said he used performance-enhancing drugs to win the Tour de France cycling race, a person familiar with the situation told The Associated Press. (AP Photo/Laurent Rebours, File)

Lance Armstrong finally comes clean about using performance-enhancing drugs during his cycling career. Here are some images chronicling his victories and the doping scandal that led to his downfall.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-01-15-Lance%20Armstrong-Photo%20Gallery/id-ff0b68a852014cb198534642d94111ac

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Tue, 15 Jan 2013 17:43:32 -0800 Drug overdose now the leading cause of death among homeless adults in Boston http://odumeuf.posterous.com/drug-overdose-now-the-leading-cause-of-death http://odumeuf.posterous.com/drug-overdose-now-the-leading-cause-of-death

Jan. 14, 2013 ? Drug overdose was the leading cause of death among homeless adults in Boston from 2003 to 2008 and accounted for one-third of deaths among those ages 25 to 44. A study by investigators from Massachusetts General Hospital (MGH) and the Boston Health Care for the Homeless Program (BHCHP) compared rates and causes of death among those served by BHCHP with data from a similar 1997 study and found that, while drug overdose had replaced HIV as the leading cause of death, overall mortality rates had not changed.

"Our findings are an unfortunate reminder of the high mortality rate of homeless people and a clarion call for the need to address the epidemic of drug overdose deaths in this vulnerable population," says Travis Baggett, MD, MPH, of the MGH Department of Medicine and BHCHP, who led the study. "Overall, young homeless people died at a nine times higher rate and middle-aged homeless people at a four-and-a-half times higher rate than comparably aged adults in Massachusetts." As a response to the study, BHCHP and the Boston Public Health Commission are leading a citywide effort to address the high number of overdose deaths from a medical and policy perspective.

The current study, which will appear in the Feb. 11 issue of JAMA Internal Medicine (formerly Archives of Internal Medicine) and is receiving early online release, updates the previous study that covered the years 1988 to 1993. That report found that HIV was the leading cause of death among BHCHP patients aged 25 to 44, while homicide was the principal cause among those 18 to 24. Heart disease and cancer were the leading causes of death in those 45 to 64. To update that data, the investigators analyzed available information for more than 28,000 adult patients who had received care from BHCHP from 2003 through 2008.

Drug overdoses accounted for almost 17 percent of all deaths among the homeless patients studied, and 81 percent of those overdoses involved opioid drugs. Cancer and heart disease -- again the primary causes of death among older homeless individuals -- each accounted for nearly 16 percent of deaths among the overall homeless population. Health issues associated with substance abuse -- such as alcoholism-associated heart disease, pneumonia and withdrawal -- accounted for 8 percent of deaths.

The significant drop in deaths from HIV infection was offset by the increase in deaths from overdoses and other substance-abuse-related issues, resulting in no change in the overall mortality rates from the earlier study. Overall mortality was higher in white individuals than in black or Hispanic homeless people, which -- the authors write -- may be due to a disproportionate burden of substance abuse and mental illness among white homeless individuals as compared to homeless minorities.

"Our results highlight the dire need to expand addiction and mental health services and to better integrate them into primary care systems serving homeless people," says Baggett, who is also an instructor in Medicine at Harvard Medical School. "They also suggest that, while health care services like BHCHP can help improve the health of homeless people, they probably are not enough. Making a major impact on mortality for these patients will also require addressing the social factors that contribute to homelessness in the first place."

Nancy Rigotti, MD, of the MGH Department of Medicine is senior author of the JAMA Internal Medicine report. Additional co-authors are James O'Connell, MD, president of BHCHP and an MGH physician; Bianca Porneala, MS, and Daniel Singer, MD, MGH Medicine; Erin Stringfellow, MSW, BHCHP; Stephen Hwang, MD, University of Toronto; and John Orav, PhD, Brigham and Women's Hospital. Funding for the study includes National Institute on Drug Abuse grant K23DA034008 and American Cancer Society grant 122269-IRG-12-070-01-IRG.

Founded in 1985, Boston Health Care for the Homeless Program has evolved into the largest and most comprehensive health care for the homeless program in the country, delivering services to more than 11,000 homeless men, women and children a year in two major teaching hospitals and more than 80 shelters and other sites.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/Cn3_STQQ3bk/130114161459.htm

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Tue, 15 Jan 2013 12:26:49 -0800 Honda offers glimpse of new small SUV http://odumeuf.posterous.com/honda-offers-glimpse-of-new-small-suv http://odumeuf.posterous.com/honda-offers-glimpse-of-new-small-suv

5 hrs.

What, you were expecting an Element redux?

Two years after ending production of the intentionally ugly-duckling boxy Element, Honda showed the Urban SUV Concept, a thinly disguised look at a new small crossover that will slot in below the CR-V in the Honda lineup at the Detroit auto show. Key competitors will be the quirky Nissan Juke and the Fiat 500L, a supersize version of the diminutive Fiat 500.

While the trucklet?s profile is similar to many other small crossovers ? including big brother CR-V ? a unique, upswept character line that suggest speed.?The as-yet unnamed production version will be built on Honda?s Global Compact Series platform, the same as the Honda Fit. Honda will also build the vehicle on the same Mexico assembly line as the Fit.

As the industry moves toward smaller vehicles with better fuel economy, small crossovers in the Urban?s class will probably proliferate. And Honda is counting on selling a lot of them. It expects the Urban to help it double worldwide production of vehicles on the Global Compact Series platform to more than 1.5 million units.?

No one has had greater success with small cars than Honda, and this Urban SUV Concept will create new value in the growing small-SUV segment,? said John Mendel, executive vice president of sales at American Honda. ?With the continued expansion of our North American manufacturing operations, we expect fuel-efficient and fun-to-drive ?small? cars to play a key role in meeting the needs of our customers in the U.S.?

The North American International Auto Show is expected to be dominated by subcompact and compact SUVs and crossovers. Click here to read about some of the other little utes that are expected to break cover at this year?s show.

The concept measures 169.3 inches long, nine inches shorter than the CR-V, which Honda says makes it ideal for ?navigating both crowded city streets and open mountain roads.?

Honda said the Urban will use its Earth Dreams Technology for increased fuel efficiency. Inside, it will feature a layout that is similar to the Fit, including its trick MagicSeat, which can be configured for a variety of passenger and cargo options. Honda did not show the vehicle?s interior, but said it will be modern and feature the latest telematics technology.

The Urban will be manufactured along with the Fit at Honda?s newest North American plant near Celaya, Mexico, expected to open in the spring of 2014. While the new SUV is targeted at the U.S. market, Honda will sell it in many other markets around the world.

More from The Detroit Bureau

Copyright ? 2009-2012, The Detroit Bureau

Source: http://www.nbcnews.com/business/honda-offers-glimpse-new-small-suv-1B7972323

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Tue, 15 Jan 2013 10:42:38 -0800 Outlook for construction industry improves in 2013 - Virginia Business http://odumeuf.posterous.com/outlook-for-construction-industry-improves-in http://odumeuf.posterous.com/outlook-for-construction-industry-improves-in

January 14, 2013 4:46 PM
• McDonnell task force begins school safety review
• Outlook for construction industry improves in 2013
• NRI Management in Richmond and Apollo Global Management join forces
• $120 million Fort Lee lodge opens in Petersburg area
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More construction firms are planning to add staff than cut staff this year, and demand for some private sector construction projects should increase, according to survey results released Monday by the Associated General Contractors of America and Computer Guidance Corp.

The survey provides a generally optimistic outlook for the year even as firms worry about rising costs and declining public sector demand for construction.
?While the outlook for the construction industry appears to be heading in the right direction for 2013, many firms are still grappling with significant economic headwinds,? Stephen E. Sandherr, the association?s CEO, said in a statement. ?With luck and a lot of work, the hard-hit construction industry should be larger, healthier, more technologically savvy and more profitable by the end of 2013 than it is today.?

Sandherr noted that significantly more firms are planning to add staff this year, 31 percent of those surveyed; compared to the number of firms expecting to make layoffs, 9 percent.

In Virginia, 33 percent of surveyed companies said they play to add staff, while another 33 percent said ?don?t know.?? If they do add staff, the companies said it would be five or fewer employees.

Compared to 2012, contractors here expect the available dollar volume of projects to be higher in 2013 in the power and hospital and higher education industries and in K-12 school construction.
This response tracks with the survey?s national results. According to Sandherr, firms are most optimistic about the outlook for hospital and higher education construction. He noted that 36 percent of firms predict the amount of money spent on those projects will grow in 2013 while 39 percent of firms expect the market will remain stable compared to last year. Contractors also were optimistic about the markets for power construction, but had lower expectations for manufacturing, private office and retail, warehouse and lodging construction.

Meanwhile, contractors expect demand for many types of public construction to decline in 2013.
A significant ? but smaller than last year ? number of contractors also report that customers? projects have been delayed or cancelled because of tight credit conditions. Forty percent of responding firms report that tighter lending conditions have forced their customers to delay or cancel construction projects. Only 3 percent of firms reported having an easier time getting credit while 41 percent report no change in credit conditions.

?Unfortunately, there are almost as many causes for concern as there are signs of optimism,? said Ken Simonson, the association?s chief economist. ?Demand for public buildings is set to decline, manufacturing work appears to be slackening, materials prices and health care costs continue to rise and many firms are reluctant to make major investments in new equipment.?

The outlook, co-sponsored by the Arlington-based trade association, was based on survey results from more than 1,300 construction firms from 49 states, the District of Columbia and Puerto Rico.

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Source: http://www.virginiabusiness.com/index.php/news/article/outlook-for-construction-industry-improves-in-2013/322374/

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Tue, 15 Jan 2013 08:56:14 -0800 Tesla Model X SUV hands-on (video) http://odumeuf.posterous.com/tesla-model-x-suv-hands-on-video http://odumeuf.posterous.com/tesla-model-x-suv-hands-on-video

Tesla Model X SUV handson video

We've seen the Model X in the flesh before, at its showy unveiling last February at which Tesla CEO Elon Musk turned up to show off the "Falcon Wing" rear doors and the rather... compact seating arrangement that makes room for three full rows of short-legged human beings. Here in Detroit at NAIAS the 2014 model year car is making another appearance, doors open and interior fully-functional. We couldn't resist hopping in there to check out the 17-inch multi-function touch panel. Largely the same as that in the Model S, the panel lets you manage climate control, navigation and, yes, do a little web surfing too. It's all demonstrated in the video after the break.

Continue reading Tesla Model X SUV hands-on (video)

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Source: http://www.engadget.com/2013/01/14/tesla-model-x-suv-hands-on/

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Wed, 26 Dec 2012 23:53:49 -0800 Private company to offer rides to moon by 2020 http://odumeuf.posterous.com/private-company-to-offer-rides-to-moon-by-202 http://odumeuf.posterous.com/private-company-to-offer-rides-to-moon-by-202

Golden Spike says it hopes to sell missions to the moon for over $1 billion.

By Clara Moskowitz,?SPACE.com / December 7, 2012

This undated image made available by NASA and photographed by the Expedition 28 crew aboard the International Space Station, shows the moon, at center with the limb of Earth near the bottom transitioning into the orange-colored troposphere, the lowest and most dense portion of the Earth's atmosphere.

NASA/AP

Enlarge

A new private venture aims to sell manned trips to the moon by 2020, its founders announced today (Dec. 6).

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The company, called Golden Spike (after the final spike built into the First Transcontinental Railroad), plans to sell each moon mission for about $1.5 billion ? a relative bargain, said the company's president and CEO Alan Stern, a former director of NASA?s Science Mission Directorate.

For the same price as many unmanned robotic missions, Golden Spike will provide a round trip for two humans to the moon.

"We're selling to nations, corporations and individuals," Stern told SPACE.com. "Get in line ? and I think it's going to be a long one." [How Golden Spike's Moon Landing Plan Works (Infographic )]

Stern and Golden Spike's chairman of the board of directors, Gerry Griffin, a former Apollo flight director and NASA Johnson Space Center director, announced their plans today at the National Press Club in Washington, D.C.

Shopping for a rocket

The company's leaders have not yet chosen a launch vehicle or space capsule to transport their passengers; Stern expects to make the final selections in 2014.

To keep costs low, Golden Spike will likely use existing or already-under-development rockets and spacecraft. However, the company will need to commission its own lunar lander and specially designed spacesuits. Stern called rumors that Golden Spike had already chosen SpaceX's Falcon 9 Heavy rocket "not true."

The company has been in the works, and under wraps, for two and a half years, Stern said.

"I don?t think anybody's got us beat," he added. "This is state-of-the-art cool."

The missions are being targeted at countries without their own space agencies or that can't afford to launch people to the moon independently, as well as scientific organizations and even private individuals looking to take the trip of a lifetime.

"We have spoken to space agencies from both Asian and European countries and found real interest," Stern said.

Private moon race

Source: http://rss.csmonitor.com/~r/feeds/science/~3/UbH0hPTO37Q/Private-company-to-offer-rides-to-moon-by-2020

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Sat, 15 Dec 2012 22:46:30 -0800 PayDay Loans Online Mag For ProAdvice and Finance News | Gold ... http://odumeuf.posterous.com/payday-loans-online-mag-for-proadvice-and-fin http://odumeuf.posterous.com/payday-loans-online-mag-for-proadvice-and-fin

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Sat, 15 Dec 2012 19:01:36 -0800 What do I do if My Toddler Gets Scabies | Simply mother And baby http://odumeuf.posterous.com/what-do-i-do-if-my-toddler-gets-scabies-simpl http://odumeuf.posterous.com/what-do-i-do-if-my-toddler-gets-scabies-simpl

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"scabies"I will never forget the time that our family had a case of scabies. If you think that lice or chicken pox are itchy then you haven?t had scabies. Scabies are tiny parasitic mites that get under a person?s skin. They spread quickly and are highly contagious. If your toddler comes home with scabies, you better treat him fast before the entire family is plagued with these unfriendly critters.

So how do you recognize scabies? Your toddler will have tiny red bumps or blisters that most of the time follow in a line. Your toddler will be scratching the area constantly with the itching becoming much worse at night and after a warm bath. Because there are so many illnesses that involve red bumps and itching (chicken pox, bug bites, and poison ivy), it is best to take your toddler to a pediatrician to confirm that the skin condition your toddler is suffering from is indeed scabies. A well-educated pharmacist may also be able to tell scabies by looking at your child?s skin, but you?ll need a prescription cream to get rid if them.

According to the Mayo Clinic, there are certain places that scabies love to hide on children. Typically, you can see them on your toddler?s scalp, face, neck, hands, and feet. Treatment is determined by the age of your child and anyone else in the home. Most pediatricians recommend treating the entire family. Permethrin is a good choice for the entire family, Crotamiton for children under the age of two, and Lindane for children over the age of two. Always follow your doctor?s orders when it comes to how much cream to use and how often.

Once you get your toddler on a treatment regimen, you will need to relieve your toddler of the uncontrollable itching associated with the scabies. Options include over-the-counter Benadryl, Calamine lotion, and cool washcloths. Always discuss these options with your pediatrician because drugs like Benadryl, while sold over-the-counter, interact with other medications in a negative way. For example, my daughter can?t take Benadryl because it interacts with her seizure medication.

Treating your toddler for scabies is only the first step. Next, you need to wash all of your toddlers clothing in hot water. Use the heat setting on your dryer as well. If your toddler has a favorite blanket or teddy bear, wash that too. Anything that can?t be washed should be bagged and set in an attic, basement, or garage for 30 days.

References:

Mayo Clinic: Scabies

Baby Center: Scabies

For information on Baby Names: Riley click here!

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Source: http://simplymotherandbaby.info/blog/what-do-i-do-if-my-toddler-gets-scabies/

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Sat, 15 Dec 2012 17:09:38 -0800 What will ad-tech look like without cookies? | PandoDaily http://odumeuf.posterous.com/what-will-ad-tech-look-like-without-cookies-p http://odumeuf.posterous.com/what-will-ad-tech-look-like-without-cookies-p

cookie monster_featureWith all the hand-wringing over ?death to the click-through rate,? the poor performance of display ads, and challenges of transferring desktop dollars to mobile, I?d say the ad tech industry has its hands full.

But there?s one creeping problem getting less attention, and it?s one that most players in the space have little control over: Cookies. There?s a quiet war being waged over the use of them, and if things keep going the way they have, many adtech startups may find their products are suddenly useless.

To provide a little oversimplified context: Websites ?drop cookies? via your Web browser as a way to record that you?ve been there. It happens on just about any site you go to. Those cookies are then used by adtech companies to sell ads. A car advertiser might bid to serve me an ad on the New York Times website if a third party company tells them I?ve already been to their website, or any car-related one. J. Crew might bid to serve me an ad on Refinery29 after I?ve abandoned a loaded shopping cart on their site. It?s called retargeting. It?s how an ad seems to follow you around the Web no matter what site you?re on. These ads are far more effective than generic ads and advertisers are willing to pay a lot for them.

They obviously don?t work when a person disables third-party cookies on their browser. But your average, non-paranoid Internet user doesn?t do this. They likely don?t even know what a cookie is or how and why to disable them. (If you think I?m being condescending, see Google?s man-on-the-street video on what a browser.)

Users might even enjoy the cookie-fied ads because they?re more relevant. I, for one, have noticed an increase in the quality of Facebook ads since it introduced retargeting from outside the site on its banner ads earlier this year. Rather than getting ads from online colleges and suspicious dentists, I see ads from sites I?ve actually visited. I hate pretty much all ads, but at least these are slightly less annoying.

It?s not actually the users that are threatening the future of cookies. It?s the browsers themselves.

Earlier this year Microsoft announced that Internet Explorer 10 will have ?Disable cookies? in its default setting. The company reiterated that stance last week. The announcement was a shock to the ad world, and the Do Not Track working group Microsoft was a part of.

Depending on who you ask, Internet Explorer still dominates the browser wars, owning 36.7 percent of the market, according to Chitika Insights; over 50 percent according to Net Applications. Anyone upgrading to IE 10 will not be trackable by third party advertisers online as the default setting.

Meanwhile Apple?s web browser, Safari, has never allowed cookies. Safari has 21 percent market share, according to Chitika. If that sounds high, it?s because this study takes mobile web browsing into account, and Apple has a particularly high market share of web browsing thanks to the dominance of the tablet and stronghold with the iPhone.

Apple does not care to spread the cookie love to third parties.?Neither does Microsoft. It?s their way of thwarting their competitor, Google, which makes the bulk of its revenue in advertising and benefits greatly from the ability to collect targeting data.

It?s worth noting here that no war is without its nuances. Microsoft?s move might not be quite as bold as it appears to be. Having the ?Do Not Track? switch automatically set to ?on? in IE 10 does not technically stop websites from dropping a cookie. It only sends a message to the website that this user does not want to be tracked. The website can ignore it and drop a cookie anyways.?Plenty of publishers, including Yahoo, have said that?s precisely what they plan to do.

The UK began requiring consent-before-cookie (my term, not theirs) earlier this year, and it?s most recent steps to enforce it have only led to confusion. ?It is thought the majority of UK websites are breaking the law that dictates how users? are tracked and logged, despite having more than a year to prepare for the changes,? ZDNet?s Zach Whittaker wrote back in May.

So how is it legal for US sites to blatantly ignore Do Not Track requests? Because the hope of any legal enforcement related to it is basically dead. For two years, groups from adtech and privacy advocates have wrestled over the issue and they?ve made almost no progress. They can?t even agree on what the definition of the word ?track? should be, let alone deciding what the key harms they are trying to solve might be.

But those choosing to heed the Do Not Track requests, should it ever actually become a law, will want an alternative to cookie-based targeting. ?Many in the industry believe cookies are a less-invasive way to advertise than the alternatives to cookies. Yes, cookies track your browsing, but they are anonymous, and they are tied to a browser, not an individual. You can review yours and clear them at any time, and they are not permanent. It may be a savvy minority that actually takes the time to review and clear browsing cookies, but they at least have the ability to do so.

That?s in contrast to the alternative options large companies may start to use if cookies ever go away,?unique ID and PII (personally identifiable information). Third party ad-tech companies (ie, startups) won?t have access to this information the way they are able to get browsing data from cookies, but giant companies like Amazon, Apple, Google and Facebook will. They have likely already gotten permission to collect it in the massive terms of service agreements we agree to. We have to consent to such terms when we boot up our new Macbooks, or when open iTunes, or when we turn on GPS for Google Maps, or when we sign up for Gmail, or when we agree to Facebook?s no-longer-democratic privacy policies, or when we put our credit card information into Amazon.

Microsoft and Safari may make life worse for Google with the war on cookies, but in doing so they also may make it worse on all of the rest of us.

erin

Erin Griffith

Erin Griffith covers New York startups for PandoDaily. She's worked as staff writer for?Adweek and?a private equity blogger for peHUB. Her writing has appeared in VCJ, Time Out New York,?Huffington Post, FT.com, and BUST. She plays keyboard in a band called Team Genius and Tweets as @Eringriffith.

Source: http://pandodaily.com/2012/12/15/what-will-ad-tech-look-like-without-cookies/

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Sat, 15 Dec 2012 02:10:38 -0800 EXCEL Tutorial | Computers & Technology http://odumeuf.posterous.com/excel-tutorial-computers-technology http://odumeuf.posterous.com/excel-tutorial-computers-technology

EXCEL TutorialDiscover an easy to use interactive software training course that will teach you how to discover the true strength of the Microsoft Excel.

This user friendly interactive course lets you study at your own pace as you cover the functions and tools of the Excel, giving you software training that will develop both your expertise and your confidence. Finally here is a way to become fluent in Microsoft Excel, a spreadsheet application that is a financial industry standard worldwide.

EXCEL COURSE Chapter 1 Covers Excel structure and ways to open and save the worksheet 1. Starting EXCEL 2. What is a spreadsheet? 3. Workbook Saving 4. Save as dialog box 5. Workbook opening 6. Open dialog box 7. New workbook opening 8. Workbook closing 9. Handling several workbooks 10. Password Chapter 2 Chapter covers data types, cells selecting, editing and marking 1. Data Types 2. Rows, Columns and cells Selecting 3. Entering data 4. Data Editing 5. Clearing Cells content 6. Cells deleting 7. Rows, Columns and cells inserting 8. Undo and Redo buttons 9. Copy Data 10. Paste Special Chapter 3 Covers ways to determine the look and design of the worksheet 1. Setting columns width 2. Setting row height 3. What is a font? 4. Underling Text 5. Bold Text 6. Italic Text 7. Text alignment 8. Worksheets navigation 9. Naming a worksheet 10. Add / delete a worksheet Chapter 4 Covers cells formations and working with worksheets 1. Moving or copying a worksheet 2. Format cells 3. Add border and color 4. Hide and Unhide 5. Freeze Panels 6. Cell rename 7. Worksheet direction Chapter 5 Covers the basic of formulas and functions 1. What is a formula? 2. Recognize a formula in a cell 3. Entering a formula 4. Relative address 5. Copy formula to cell region?


Read more?

Posted by Dan on Thursday, December 13, 2012 at 4:14 pm?
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Source: http://www.theyellowads.com/computers_technology/excel-tutorial/

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Fri, 14 Dec 2012 18:43:33 -0800 Official: Family has identified Rivera remains http://odumeuf.posterous.com/official-family-has-identified-rivera-remains http://odumeuf.posterous.com/official-family-has-identified-rivera-remains

MONTERREY, Mexico (AP) ? A state official says Jenni Rivera's family has identified the remains of the Mexican-American music star killed in plane crash.

Nuevo Leon state security spokesman Jorge Domene said DNA tests are still pending. The singer's remains will be given to the family once the tests are completed in coming days.

Officials said earlier that two state police officers had been arrested on suspicion of stealing unspecified items from the scene of the plane crash that killed Rivera.

The Nuevo Leon state government says authorities found images of the scene on the smartphone of one of the officers, who is 23, while trying to determine now the Mexican media got photographs of the secured site, including images of body parts and personal documents.

Source: http://news.yahoo.com/official-family-identified-rivera-remains-222608143.html

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Fri, 14 Dec 2012 16:50:21 -0800 SAfrica president: Nelson Mandela 'recuperating' http://odumeuf.posterous.com/safrica-president-nelson-mandela-recuperating http://odumeuf.posterous.com/safrica-president-nelson-mandela-recuperating

BLOEMFONTEIN, South Africa (AP) ? South African President Jacob Zuma says anti-apartheid icon Nelson Mandela is "recuperating" after falling ill from a recurring lung infection.

Zuma made the comments Thursday while renaming an airport in Bloemfontein.

Zuma said Mandela "is recuperating from a lung infection at a Pretoria hospital. We wish him a speedy recovery and assure him yet again, of the love and support of many in the country and abroad."

Mandela is 94 years old and was admitted Saturday to 1 Military Hospital near South Africa's capital, Pretoria.

Mandela is revered for being a leader of the struggle against racist white rule in South Africa and for preaching reconciliation once he emerged from prison in 1990 after 27 years. He served one five-year term as president before retiring from public life.

Source: http://news.yahoo.com/safrica-president-nelson-mandela-recuperating-104622508.html

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Fri, 14 Dec 2012 00:13:04 -0800 Experimental agent briefly eases depression rapidly in test http://odumeuf.posterous.com/experimental-agent-briefly-eases-depression-r http://odumeuf.posterous.com/experimental-agent-briefly-eases-depression-r Thursday, December 13, 2012

A drug that works through the same brain mechanism as the fast-acting antidepressant ketamine briefly improved treatment-resistant patients' depression symptoms in minutes, with minimal untoward side effects, in a clinical trial conducted by the National Institutes of Health. The experimental agent, called AZD6765, acts through the brain's glutamate chemical messenger system.

Existing antidepressants available through prescription, which work through the brain's serotonin system, take a few weeks to work, imperiling severely depressed patients, who can be at high risk for suicide. Ketamine also works in hours, but its usefulness is limited by its potential for dissociative side-effects, including hallucinations. It is being studied mostly for clues to how it works.

"Our findings serve as a proof of concept that we can tap into an important component of the glutamate pathway to develop a new generation of safe, rapid-acting practical treatments for depression," said Carlos Zarate, M.D., of the NIH's National Institute of Mental Health, which conducted the research.

Zarate, and colleagues, reported on their results online Dec. 1, 2012 in the journal Biological Psychiatry.

AZD6765, like ketamine, works by blocking glutamate binding to a protein on the surface of neurons, called the NMDA receptor. It is a less powerful blocker of the NMDA receptor, which may be a reason why it is better tolerated than ketamine.

About 32 percent of 22 treatment-resistant depressed patients infused with ASD6765 showed a clinically meaningful antidepressant response at 80 minutes after infusion that lasted for about half an hour ? with residual antidepressant effects lasting two days for some. By contrast, 52 percent of patients receiving ketamine show a comparable response, with effects still detectable at seven days. So a single infusion of ketamine produces more robust and sustained improvement, but most patients continue to experience some symptoms with both drugs.

However, depression rating scores were significantly better among patients who received AZD6765 than in those who received placebos. The researchers deemed this noteworthy, since, on average, these patients had failed to improve in seven past antidepressant trials, and nearly half failed to respond to electroconvulsive therapy (ECT).

The patients reported only minor side effects, such as dizziness and nausea, which were not significantly different from those experienced with the placebo.

Zarate and colleagues say their results warrant further trials with AZD6765, testing whether repeated infusions a few times per week or higher doses might produce longer-lasting results.

###

A Randomized Trial of a Low-Trapping Nonselective N-Methyl-D-Aspartate Channel Blocker in Major Depression. Zarate CA Jr, Mathews D, Ibrahim L, Chaves JF, Marquardt C, Ukoh I, Jolkovsky L, Brutsche NE, Smith MA, Luckenbaugh DA. Biol Psychiatry. 2012 Nov 30. doi:pii: S0006-3223(12)00941-9. 10.1016/j.biopsych.2012.10.019. [Epub ahead of print] PMID: 23206319

NIH/National Institute of Mental Health: http://www.nimh.nih.gov

Thanks to NIH/National Institute of Mental Health for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/125907/Experimental_agent_briefly_eases_depression_rapidly_in_test

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Thu, 13 Dec 2012 18:37:06 -0800 Leading conservative says Obama will win tax fight http://odumeuf.posterous.com/leading-conservative-says-obama-will-win-tax http://odumeuf.posterous.com/leading-conservative-says-obama-will-win-tax

WASHINGTON (AP) ? A leading conservative who's resigning from the Senate is predicting that President Barack Obama will win the battle over raising taxes.

South Carolina Republican Jim DeMint calls it "a political trophy" within Obama's grasp. Appearing Thursday on "CBS This Morning," DeMint says, quote, "The president's proposal is not a plan, it's not a solution."

Asked why Obama and congressional Republicans can't agree on a plan to avert a fiscal cliff in less than three weeks, DeMint says both political parties have "failed" the country.

On Obama, the senator says, "He's going to get his wish. I believe we're going to be raising taxes and not just on the top earners."

DeMint is stepping down from the Senate to become president of the Heritage Institution, a conservative think tank.

Source: http://news.yahoo.com/leading-conservative-says-obama-win-tax-fight-122102345--politics.html

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Thu, 13 Dec 2012 16:46:48 -0800 Life Design: Relationships & Communication Maven Deb Dutilh! 12 ... http://odumeuf.posterous.com/life-design-relationships-communication-maven http://odumeuf.posterous.com/life-design-relationships-communication-maven
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    Live at 1pm ET. The ConVo will feature a discussion with SVP of Social Media for Citibank, Frank Eliason. Start your 2013 with social marketing tips from a pro. Join The ConVo.

  • As the new season of the hit show Impractical Jokers nears two stars of the show Murr & Joe join us to discuss what makes the show so successful and what we can look forward to with the new season!

  • Grammy Award-winning and multi-platinum hit songwriter/producer LaShawn Daniels and hairstylist wife April, who are both starring in WE's network's, "Tamar & Vince," drop by to talk with Olivia Wilder about their hit show.

  • Are you happy right now? Best Ever You happily welcomes Luann Robinson Hull, who is here to talk about her award winning book ?Happily Every After Right Now?Stop Searching Start Celebrating"

  • Sarah Winchester from Real Housewives of Orange County Hosts Sarah's Secrets on @Ezwaybroadcast. Celebrity Gossip, Fashion, Relationship Advice and more. Special guests include Shangela Laquifa & Steven Skyler from Glee. Plus Sarah's Scandal chat.Every Wed @ 3

  • The Power Is Now welcomes guest speaker Louis Amaya, Co-Founder/CEO of iServe Companies. The Power Is Now Online Radio is a weekly Radio Program about Real Estate for Real Estate Professionals.

  • Critics Rebecca Theodore-Vachon (The Urban Daily & Cinema in Noir) and Shawn Edwards (BFCA & FOX 4 Kansas City) will join host Tim Gordon to break down the best films and performances by Black filmmakers and actors for Black Reel Awards consideration.

  • You know him from the group Day 26 but Anthony Q is now a solo artist creating the music he wants. He talks with Conversations LIVE host Cyrus Webb about his music, his success and what's to come for his fans.

  • Life After Dusk Live welcomes Actor/Artist, Khleo Thomas who is known for his breakout role as "Zero" in Disney's "Holes" and signed to record label "Dream Big, Hustle Hard". Khleo will share how he has been able to be successful in both the acting and music w

  • Let's Do Lunch! visits Jacksonville, Florida to the Casa Marina hotel and their fabulous Penthouse Restaurant. Executive Chef Aaron Webb, celebrating 15 years, and Kyle McManus behind the bar join host Robin Milling for a delicious seafood and martini tasting.

  • From conversations with world figures to to inspiring the next generation of leaders, Tavis Smiley continues is an outstanding voice for change. TIME Magazine honored Smiley in 2009 as one of "The World's 100 Most Influential People."

  • Chris Lambton from HGTV's 'Going Yard' talks winter yard care tips and getting his house ready for holidays with his wife Peyton. Hosts Mark and Theresa share DIY know-how that will help you avoid winter troubles and get your home in top shape for the season.

  • Actor James Mapes has starred in films such as "Taxi Driver","Pelham 1,2,3" and his latest project is "The Wicker Tree", He is the founder of Quantum Leap Thinking, creator of The Transformation CoachTM,best selling author,highly acclaimed business speaker

  • Tonight on "He Said, She Said", Monica Crowley of FoxNews' "The Five" sits down with Demetrius & Stacy to discuss the current fiscal situation in Washington, and much more!

  • Just one week after discovering her Grammy nomination for Gospel Album of the year recording artist stops by Conversations LIVE to talk with host Cyrus Webb about the honor, the year and what's to come.

  • The Sy Effect Radio Show welcomes Peter Bailey, Journalist, Author and Host of NiteCap - as seen on NBC, Huffington Post and MTV to name a few; where he shares real conversations with some of the most talented and successful entertainers of today.

  • On-Air with Douglas visits with singer-songwriter, Jason Castro, who was the fourth place finalist on season seven of American Idol. He has a brand new album, "Only A Mountain" coming out in January. He will talk about his career from pre to post Idol. Fans call in!

  • Join us for an evening with John Trudell, Native American Warrior, writer, singer, poet and advocate for positive change in Indian Country: and a Celebration for Leonard Peltier and the upcoming concert on Friday December 14th at the Beacon Theatre in New York

  • Tune in to listen to Season 2, Episode 2 of Verses and Flow with Luke James, and spoken word by Omar Holmon, Tasha Jones and Javon Johnson Brought to you by Lexus

  • Source: http://www.blogtalkradio.com/authenticyouradio/2012/12/13/life-design-relationships-communication-maven-deb-dutilh

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    Thu, 13 Dec 2012 09:25:11 -0800 It's 12/12/12: That's bad ? and good http://odumeuf.posterous.com/its-121212-thats-bad-and-good http://odumeuf.posterous.com/its-121212-thats-bad-and-good

    A seemingly benign number that defines everything from a dozen eggs and the hours of day and night to the days of Christmas and the astrological signs, 12 may be in the spotlight today, 12/12/12.

    This date structure, in which the same two-digit number gets repeated three times, won't happen again until 2112, according to the Astronomical Society of the Pacific (ASP).

    But does the triple dose of 12 hold any meaning? Depends on whom you ask, but in Hong Kong and Singapore, couples are crowding the aisles for a chance to tie the knot on a day they say symbolizes love, according to news outlets. Las Vegas is also abuzz with nuptials, according to CNN, which also reported an Indian numerologist saying today is a great day to start a new business venture. Making the rounds online, a boy who will turn 12 today at 12:12 p.m. in Bronxville, N.Y., suggests we're all a bit "number crazy."

    1. Science news from NBCNews.com

      1. Here's the real-life face of a 'Hobbit'

        Researchers have revealed what the face of a controversial ancient human nicknamed "the Hobbit" might have looked like.

      2. Serbian mountain draws 'Doomsday' crowd
      3. Brain cells made from human urine
      4. Hawking, CERN scientists win big physics prizes

    Doom isn't far behind the celebrations. While most believers in the Mayan apocalypse think the end of the world will come on Dec. 21, 2012, apparently some have interpreted the end of the Maya Long Count calendar differently, pinpointing Dec. 12, 2012, as a day of reckoning. (There is no evidence to suggest the Mayans predicted the end of their calendar to mean the end of the world.)

    Turning doomsday on its head, the ASP has coined today "Anti-Doomsday."

    "While many pundits and prognosticators lament the supposed end of the world on Dec. 21, 2012 (thanks to misinterpreting Mayan predictions), here at the ASP we encourage everyone to go in the opposite ? and accurate ? direction. Thus, we are declaring Dec. 12, 2012 as Anti-Doomsday Day in celebration of rational thinking and reasoned discourse," according to an ASP statement. [ End of the World? Top Doomsday Fears ]

    And if one were to tie any significance to today, and numerology in general, the ASP reminds us of plenty of auspicious associations with the number 12: the months in a year on contemporary calendars; 12 traditional zodiac signs; 12 Olympic gods and goddesses in Greek mythology; and 12 bottles of wine in a case. In Christian belief, Jesus had 12 apostles.

    Then there's Mars, which is 12 light-minutes from the sun, and Jupiter, which takes 12 years to orbit the sun, according to the ASP.

    The most recent triple-digit setup like today's occurred on Nov. 11, 2011 ( 11/11/11 ), another day some associated with Mayan doom. That day most likely became linked with Dec. 21, 2012, when believers noticed that the U.S. Naval Observatory had set the exact time of the 2012 winter solstice ? when Earth's tilt is angled at its farthest from the sun ? for 11:11 Universal Time on Dec. 21, John Hoopes, a scholar of Maya history at the University of Kansas, told LiveScience last year. (The Observatory now lists the official time for the winter solstice at 11:12 Universal Time.)

    While the meaning behind numbers, called numerology, has yet to be grounded in science, humanity seems hard-wired to find such numerical associations.

    "Cognitive scientists have demonstrated that our brains are hard-wired to look for meaningful patterns in the sensory data it collects from the world," said Alan Lenzi, professor of religious studies at University of the Pacific. "Numbers that are already significant to us, such as calendar dates, that also coincidentally fall into an obvious pattern become doubly significant," Lenzi told LiveScience in 2011, speaking about 1/11/11.

    Lenzi added, "Given the propensity for people to look for significance in particular days and times (e.g. the "end of the world"), patterns are easily imbued with imaginative meaning," Lenzi said.

    And patterns tend to stick in our heads ? you're more likely to remember a birthday that's on 11/11, 12/12, or 10/10, than one on 12/5, for instance. The same would be the case for various times of the day. "People are more likely to remember 11:11 than they are, say, 4:29 or 6:53 or 3:17 or something like that," Hoopes said.

    Follow LiveScience on Twitter @livescience. We're also on Facebook? and Google+.

    Source: http://www.msnbc.msn.com/id/50175929/ns/technology_and_science-science/

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    Wed, 12 Dec 2012 18:30:57 -0800 Women slow to make gains in boardrooms http://odumeuf.posterous.com/women-slow-to-make-gains-in-boardrooms http://odumeuf.posterous.com/women-slow-to-make-gains-in-boardrooms

    8 hrs.

    NEW YORK--?Although women make up nearly half of the U.S. workforce, only 16.6 percent have seats on the boards of Fortune 500 companies and the number has barely budged since 2005, according to a study released on Tuesday.

    The Catalyst 2012 F500 Census, which annually tracks women in top positions in companies, showed progress is painfully slow for women seeking the top spots in corporate America, with only a 0.5 percent rise from the previous year.

    "What we found is that the needle barely budged for women aspiring into corporate board service or into top-level leadership at these very prominent American companies," said Rachel Soares, a senior research associate at Catalyst, a nonprofit group.

    "In 2012 women held only 16.6 percent of board seats and only 14.3 percent of executive officer positions."

    The number of women executives last year was slightly lower than in 2010 and only marginally better than in 2011. During the past two years more than a quarter of U.S. companies had no women executive officers, according to the research, and just one-fifth had 25 percent or more.

    Improvement at a snail's pace
    Women's advancement into boardrooms and executive offices has been slow since Catalyst, which works to expand opportunities for women and businesses, started with the F500 Census in 1993. In 2005 it slowed to a snail's pace, with half or less than half of a percentage point gain each year.

    "It is not meaningful. It is not significant," Soares said of the lack of progress in closing the gender leadership gap.

    For women of color, the situation is even worse, with 3.3 percent holding board seats in 2012, up 0.3 percent from 2011.

    "It just underscores the challenges that women face, particularly at the intersection of different dimensions of diversity, in this case gender and race/ethnicity," said Soares.

    In 2011 and 2012 two-thirds of companies did not have any women of color serving on their boards.

    Catalyst compiled the results by studying the top 500 U.S. companies ranked by revenues by Fortune magazine and counting everyone on boards and in top executive positions, noting their gender and race/ethnicity. Three companies were excluded because data was not available.

    Plenty of qualified women
    Although many barriers block women's entry to boardrooms and executive offices, Catalyst research showed that sponsorship is critical to advancing women, as is the commitment of current leadership.

    "Our data shows that between 2009 and 2011, 81 percent of (board) seats that were filled went to men. The pool that companies were drawing from is not taking advantage of the full range of women with their skills that are available," Deborah Gillis, chief operating officer of Catalyst, said in an interview.

    To pry open the door further and break through the relationship barrier, Catalyst is compiling a directory of board-qualified women based on recommendations from sponsors and companies.

    "What we are saying with this list is that the under-representation of women on corporate boards is not about a lack of supply. That's a myth," said Gillis.

    "In fact, if we look at the executive officer pool, we see 710 women executive officers in Fortune 500 companies. It is an extensive pool of women with skills and experience in critical areas that corporate boards could tap into."

    Source: http://www.nbcnews.com/business/women-slow-make-gains-boardrooms-1C7562530

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    Wed, 12 Dec 2012 16:45:54 -0800 Epigenetics may be a critical factor contributing to homosexuality, study suggests http://odumeuf.posterous.com/epigenetics-may-be-a-critical-factor-contribu http://odumeuf.posterous.com/epigenetics-may-be-a-critical-factor-contribu

    Dec. 11, 2012 ? Epigenetics -- how gene expression is regulated by temporary switches, called epi-marks -- appears to be a critical and overlooked factor contributing to the long-standing puzzle of why homosexuality occurs.

    According to the study, published online today in The Quarterly Review of Biology, sex-specific epi-marks, which normally do not pass between generations and are thus "erased," can lead to homosexuality when they escape erasure and are transmitted from father to daughter or mother to son.

    From an evolutionary standpoint, homosexuality is a trait that would not be expected to develop and persist in the face of Darwinian natural selection. Homosexuality is nevertheless common for men and women in most cultures. Previous studies have shown that homosexuality runs in families, leading most researchers to presume a genetic underpinning of sexual preference. However, no major gene for homosexuality has been found despite numerous studies searching for a genetic connection.

    In the current study, researchers from the Working Group on Intragenomic Conflict at the National Institute for Mathematical and Biological Synthesis (NIMBioS) integrated evolutionary theory with recent advances in the molecular regulation of gene expression and androgen-dependent sexual development to produce a biological and mathematical model that delineates the role of epigenetics in homosexuality.

    Epi-marks constitute an extra layer of information attached to our genes' backbones that regulates their expression. While genes hold the instructions, epi-marks direct how those instructions are carried out -- when, where and how much a gene is expressed during development. Epi-marks are usually produced anew each generation, but recent evidence demonstrates that they sometimes carry over between generations and thus can contribute to similarity among relatives, resembling the effect of shared genes.

    Sex-specific epi-marks produced in early fetal development protect each sex from the substantial natural variation in testosterone that occurs during later fetal development. Sex-specific epi-marks stop girl fetuses from being masculinized when they experience atypically high testosterone, and vice versa for boy fetuses. Different epi-marks protect different sex-specific traits from being masculinized or feminized -- some affect the genitals, others sexual identity, and yet others affect sexual partner preference. However, when these epi-marks are transmitted across generations from fathers to daughters or mothers to sons, they may cause reversed effects, such as the feminization of some traits in sons, such as sexual preference, and similarly a partial masculinization of daughters.

    The study solves the evolutionary riddle of homosexuality, finding that "sexually antagonistic" epi-marks, which normally protect parents from natural variation in sex hormone levels during fetal development, sometimes carryover across generations and cause homosexuality in opposite-sex offspring. The mathematical modeling demonstrates that genes coding for these epi-marks can easily spread in the population because they always increase the fitness of the parent but only rarely escape erasure and reduce fitness in offspring.

    "Transmission of sexually antagonistic epi-marks between generations is the most plausible evolutionary mechanism of the phenomenon of human homosexuality," said the study's co-author Sergey Gavrilets, NIMBioS' associate director for scientific activities and a professor at the University of Tennessee-Knoxville.

    The paper's other authors are William Rice, a professor at the University of California, Santa Barbara, and Urban Friberg, a professor at Uppsala University in Sweden.

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    The above story is reprinted from materials provided by National Institute for Mathematical and Biological Synthesis (NIMBioS).

    Note: Materials may be edited for content and length. For further information, please contact the source cited above.


    Journal Reference:

    1. William R. Rice, Urban Friberg, and Sergey Gavrilets. Homosexuality as a Consequence of Epigenetically Canalized Sexual Development. The Quarterly Review of Biology, 2012; 87 (4) [link]

    Note: If no author is given, the source is cited instead.

    Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

    Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/xKLRDHovvmA/121211083212.htm

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